Sarcosine → 1-Methyl-1-(hydroxycarbonylmethyl)-3-(3,4-dichlorophenyl) urea

HRID 67246

反応式

HRID 67246 の反応式
[NH:1]([CH2:3][C:4]([OH:6])=[O:5])[CH3:2].[OH-].[Na+].[Cl:9][C:10]1[CH:11]=[C:12]([N:17]=[C:18]=[O:19])[CH:13]=[CH:14][C:15]=1[Cl:16]>O>[CH3:2][N:1]([CH2:3][C:4]([OH:6])=[O:5])[C:18]([NH:17][C:12]1[CH:13]=[CH:14][C:15]([Cl:16])=[C:10]([Cl:9])[CH:11]=1)=[O:19]

参加物

5

反応物 3

HCID 1088SarcosineHCID 76073,4-Dichlorophenyl isocyanateHCID 14798Sodium Hydroxide

生成物 1

HCID 167751521-Methyl-1-(hydroxycarbonylmethyl)-3-(3,4-dichlorophenyl) urea

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred solution of 89 g. of sarcosine in 300 ml. of water containing 60 g. of sodium hydroxide were added portion-wise over thirty minutes 188 g. of 3,4-dichlorophenyl isocyanate. The reaction mixture was stirred for thirty minutes following the addition, and then was filtered. The filtrate was acidified with concentrated hydrochloric acid, whereupon a white solid precipitated. The solid was collected by filtration and air dried to give 1-methyl-1-(hydroxycarbonylmethyl)-3-(3,4-dichlorophenyl) urea. M.P. 103°-105° C.

後処理

  1. additionthe addition
  2. filtrationwas filtered
  3. customprecipitated
  4. filtrationThe solid was collected by filtration and air
  5. customdried

出典と根拠

ORDレコード
ord-6f0f20cc3cf14ba38986caa0dbd07a05
出典データセット
uspto-grants-1982_08
特許番号
US04345936

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