Hydracrylonitrile → 2-Cyanoethyl prop-2-ynoate

HRID 67713

反応式

HRID 67713 の反応式
[C:1]([OH:5])(=[O:4])[C:2]#[CH:3].[C:6](#[N:10])[CH2:7][CH2:8]O>C1(C)C=CC(S(O)(=O)=O)=CC=1.C(Cl)(Cl)Cl>[C:1]([O:5][CH2:8][CH2:7][C:6]#[N:10])(=[O:4])[C:2]#[CH:3]

参加物

5

反応物 2

HCID 8011HydracrylonitrileHCID 10110Propiolic Acid

生成物 1

HCID 204932242-Cyanoethyl prop-2-ynoate収率 29%

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 6212Chloroform溶媒

実験手順

A solution of 98 g of propiolic acid (1.4 moles), 99.5 g of hydracrylonitrile (1.4 moles), 2 g of p-toluenesulfonic acid and 200 ml of chloroform were refluxed, using a Soxhlet extractor filled with 3 A molecular sieves to remove the water generated during the esterification. A total reflux time of 94 hours was employed. The reaction was cooled, poured into water and extracted with chloroform. The combined extracts were washed with dilute bicarbonate solution, dried (MgSO4), and concentrated to give 49.2 g (29 percent) of a liquid used without purification.

後処理

  1. additionfilled with 3 A molecular sieves
  2. customto remove the water
  3. customA total reflux time of 94 hours
  4. temperatureThe reaction was cooled
  5. additionpoured into water
  6. extractionextracted with chloroform
  7. washThe combined extracts were washed with dilute bicarbonate solution
  8. dry with materialdried (MgSO4)
  9. concentrationconcentrated

出典と根拠

ORDレコード
ord-4a87bb4296684e359b17c6a0c3e00635
出典データセット
uspto-grants-1982_08
特許番号
US04346161

関連ノート

読み込み中…