1,4-Dichlorobenzene → 2-Bromo-1,4-dichlorobenzene

HRID 68021

反応式

HRID 68021 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5]C1C=CC=CC=1.[CH:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([Cl:19])[CH:13]=1.[Br:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[C:22]=1[Br:29]>[Fe]>[Br:29][C:22]1[CH:21]=[CH:26][C:25]([Cl:18])=[CH:24][C:23]=1[Cl:28].[Br:5][C:15]1[CH:16]=[C:17]([Cl:18])[CH:12]=[CH:13][C:14]=1[Cl:19].[Br:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=1

参加物

8

反応物 4

HCID 46851,4-DichlorobenzeneHCID 7961BromobenzeneHCID 6451240Aluminum(III) ChlorideHCID 140296631,2-dibromo-3,4-dichlorobenzene

生成物 3

HCID 150332-Bromo-1,4-dichlorobenzeneHCID 290134-Bromo-1,2-dichlorobenzeneHCID 709471-Bromo-2,4-dichlorobenzene

試薬・触媒・溶媒 1

HCID 23925Iron触媒

実験手順

The o-, m- or p-dichlorobenzenes or mixture thereof which is used as intermediates for syntheses of various organic compounds is brominated at 0° to 100° C. in the presence of aluminum chloride, ferric chloride or iron powder. The bromobenzene is chlorinated in the same condition. The dichlorobenzene is reacted with the dibromodichlorobenzene in the presence of an aluminum halide for 1 to 5 hours. In these methods, 1-bromo-2,4-dichlorobenzene, 1-bromo-2,5-dichlorobenzene, and 1-bromo-3,4-dichlorobenzene etc. can be obtained in high yield.

出典と根拠

ORDレコード
ord-12b808519d014a45884e6fff12f972d8
出典データセット
uspto-grants-1982_08
特許番号
US04347390

関連ノート

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