Iodine → 6-Iodo-3,4-dihydroquinolin-2(1H)-one

HRID 6812

反応式

HRID 6812 の反応式
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+].[Ag+]>[I:12][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[NH:1][C:2](=[O:11])[CH2:3][CH2:4]2

参加物

5

反応物 2

HCID 807IodineHCID 64796Hydrocarbostyril

生成物 1

HCID 220189516-Iodo-3,4-dihydroquinolin-2(1H)-one

試薬・触媒・溶媒 2

HCID 159865Silver sulfate触媒HCID 702Ethanol溶媒2 回

実験手順

3,4-Dihydroquinolin-2(1H)-one (7.5 g; 51 mmol) and silver (I) sulfate (17.5 g; 56.1 mmol) were suspended in ethanol (250 mL). A solution of iodine in ethanol (250 mL) was added slowly to the reaction over 1 hour. After 6 hours, the reaction was filtered through CELITE diatomaceous earth and washed copiously with methanol. The volatiles were removed under vacuum and the crude residue was triturated with ether. The solids were collected on a fritted funnel and dried under vacuum. This provided the title compound.

後処理

  1. filtrationthe reaction was filtered through CELITE diatomaceous earth
  2. washwashed copiously with methanol
  3. customThe volatiles were removed under vacuum
  4. customthe crude residue was triturated with ether
  5. customThe solids were collected on a fritted funnel
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-d57d16896f9f4187ad5a58a2a543f654
出典データセット
uspto-grants-2006_08
特許番号
US07084156B2

関連ノート

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