4-(4-Nitrophenyl)-morpholin-3-ON → 4-(4-Aminophenyl)morpholin-3-one

HRID 68467

反応式

HRID 68467 の反応式
[N:1]1([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7].[H][H]>O1CCCC1.[Pd]>[N:1]1([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7]

参加物

5

反応物 2

HCID 114473754-(4-Nitrophenyl)-morpholin-3-ONHCID 178418361HCID 178418361、化合物

生成物 1

HCID 111948544-(4-Aminophenyl)morpholin-3-one収率 37.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

In an autoclave, 63 g (0.275 mol) of 4-(4-morpholin-3-onyl)nitrobenzene are dissolved in 200 ml of tetrahydrofuran, admixed with 3.1 g of Pd/C (5% ig) and hydrogenated at 70° C. and a hydrogen pressure of 50 bar for 8 h. The catalyst is filtered off, the solvent is then distilled off under reduced pressure and the product is purified by crystallization from ethyl acetate. 20 g of product are obtained as a colourless to bluish solid, in a yield of 37.6% of theory.

後処理

  1. filtrationThe catalyst is filtered off
  2. distillationthe solvent is then distilled off under reduced pressure
  3. customthe product is purified by crystallization from ethyl acetate

出典と根拠

ORDレコード
ord-5424d5fc9d7d43dda5c78c8b21573aaf
出典データセット
uspto-grants-2014_09
特許番号
US08822458B2

関連ノート

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