Water → 1,3-Propanedione, 1,3-bis(4-fluorophenyl)-

HRID 68558

反応式

HRID 68558 の反応式
CC([O-])(C)C.[K+].[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)=[O:9].C[O:18][C:19](=O)[C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1.O>C1COCC1>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C:8](=[O:9])[CH2:7][C:19]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)=[O:18])=[CH:11][CH:12]=1

参加物

6

反応物 4

HCID 962WaterHCID 98284'-FluoroacetophenoneHCID 67878Methyl 4-fluorobenzoateHCID 23665647Potassium tert-butoxide

生成物 1

HCID 738961,3-Propanedione, 1,3-bis(4-fluorophenyl)-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

9.27 g KOtBu was added to 109 mg 18-Krone-6 and 5 mL 4-fluoracetophenone in 150 mL THF. After 30 min at RT 10.7 g 4-fluoro-benzoic acid methyl ester was added and stirred for 3 h at RT. The reaction was decomposed with water and filtered, the filtrate was concentrated and the residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2). The solvent was removed and 3.9 g of the desired compound was obtained.

後処理

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated
  3. customthe residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2)
  4. customThe solvent was removed

出典と根拠

ORDレコード
ord-70cfdcee53bf4b3191c40dab3dfbd6eb
出典データセット
uspto-grants-2014_09
特許番号
US08822464B2

関連ノート

読み込み中…