4-Fluoro-3-nitrobenzoic acid → 3-Amino-4-fluorobenzoic acid
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[F:13])[C:7]([OH:9])=[O:8])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[F:13])[C:7]([OH:9])=[O:8]参加物
4
実験手順
A mixture of 3-nitro-4-fluorobenzoic acid (1.85 g, 10.0 mmol) in MeOH (10 mL) and 5% Pd/C (100 mg) was stirred under an atmosphere of hydrogen and for 6 h. The catalyst was removed by filtration, washed with methanol and the volatiles were removed in vacuo to give compound 8A, 3-amino-4-fluorobenzoic acid, as a light yellow solid (1.50 g, 9.67 mmol, 97%).
後処理
- customThe catalyst was removed by filtration
- washwashed with methanol
- customthe volatiles were removed in vacuo
出典と根拠
- ORDレコード
- ord-67fc0467b9744c9cae8a4d6ce0d4b91d
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084160B2
反応ノート
読み込み中…