Acetonitrile → HCID 58452310、化合物

HRID 70529ノート

反応式

HRID 70529 の反応式
C(#N)C.[C:4]([C:8]1[CH:13]=[CH:12][C:11](/[C:14](/[C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([O:26][CH3:27])[N:20]=2)=[CH:15]\C(O)=O)=[CH:10][CH:9]=1)([CH3:7])([CH3:6])[CH3:5].[Br:28]N1C(=O)CCC1=O>C(N(CC)CC)C>[Br:28]/[CH:15]=[C:14](/[C:19]1[N:20]=[C:21]([O:26][CH3:27])[C:22]([Cl:25])=[CH:23][CH:24]=1)\[C:11]1[CH:12]=[CH:13][C:8]([C:4]([CH3:7])([CH3:6])[CH3:5])=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 67184N-bromobutanimideHCID 58452337(2E)-3-(4-tert-Butylphenyl)-3-(5-chloro-6-methoxypyridin-2-yl)prop-2-enoic acid

生成物 1

HCID 58452310HCID 58452310、化合物収率 25.4%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A 97% acetonitrile solution (52 mL) containing triethylamine (26 μL) was added to (2E)-3-(4-tert-butylphenyl)-3-(5-chloro-6-methoxypyridin-2-yl)prop-2-enoic acid (1.3 g). N-bromosuccinimide (806 mg) was added thereto and the mixture was stirred at room temperature for 15 minutes. The solvent was evaporated under reduced pressure from the reaction solution. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to give the title compound as a colorless powder (363 mg, 25%).

後処理

  1. customThe solvent was evaporated under reduced pressure from the reaction solution
  2. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1)

出典と根拠

ORDレコード
ord-3967e97791ca43dfbfb76ec8b4b55a3d
出典データセット
uspto-grants-2014_09
特許番号
US08822503B2

反応ノート

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