Tetrahydrofuran → N-(4-(2-Hydroxyethylidene)cyclohexyl)acetamide

HRID 705427

反応式

HRID 705427 の反応式
[H-].[Na+].O=[C:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:13])[CH3:12])[CH2:6][CH2:5]1.C1C[O:17][CH2:16][CH2:15]1>>[OH:17][CH2:16][CH:15]=[C:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:13])[CH3:12])[CH2:6][CH2:5]1

参加物

4

反応物 3

HCID 8028Tetrahydrofuran2 回HCID 24758Sodium hydrideHCID 538565N-(4-Oxocyclohexyl)acetamide

生成物 1

HCID 58294115N-(4-(2-Hydroxyethylidene)cyclohexyl)acetamide

実験手順

To a stirred suspension of sodium hydride (1.2 mmol) in THF was added triethyl phosphonoacetate (1.2 mmol) drop wise. The mixture was allowed to stir until it became colorless and a solution of N-(4-oxocyclohexyl)acetamide (1.0 mmol) in THF (1 mL) was added. The solution was allowed to stir at rt until the reaction was complete (by TLC). The solvent was removed under reduced pressure and the crude residue was filtered through a small plug of silica gel to afford the desired product, which was used directly in the next synthetic step.

後処理

  1. stirringto stir at rt until the reaction
  2. customThe solvent was removed under reduced pressure
  3. filtrationthe crude residue was filtered through a small plug of silica gel

出典と根拠

ORDレコード
ord-72bbb327ed704c298243c30a6e3bbc83
出典データセット
uspto-grants-2015_11
特許番号
US09174942B2

関連ノート

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