Trifluoroacetic acid → HCID 67399462、化合物
反応式
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[CH:11][C:12](/[C:17](/[C:24]2[CH:29]=[CH:28][C:27]([S:30]([N:33]3[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]3)(=[O:32])=[O:31])=[CH:26][CH:25]=2)=[CH:18]/[CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[N:13][C:14]=1[O:15][CH3:16]>C(Cl)(Cl)Cl>[Cl:8][C:9]1[CH:10]=[CH:11][C:12](/[C:17](/[C:24]2[CH:29]=[CH:28][C:27]([S:30]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)(=[O:31])=[O:32])=[CH:26][CH:25]=2)=[CH:18]/[CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[N:13][C:14]=1[O:15][CH3:16]参加物
4
実験手順
Trifluoroacetic acid (0.2 mL) was added to a solution of tert-butyl 4-({4-[(E)-1-(5-chloro-6-methoxypyridin-2-yl)-2-cyclopentylethenyl]phenyl}sulfonyl)piperazine-1-carboxylate (178 mg) in chloroform (3 mL), and the mixture was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to give 1-({4-[(E)-1-(5-chloro-6-methoxypyridin-2-yl)-2-cyclopentylethenyl]phenyl}sulfonyl)piperazine as a crude product.