5-Aminobenzimidazole → 5-(4-(2-methoxyethoxy)phenyl)-1-(1H-benzo[d]imidazol-5-yl)imidazolidin-2-one

HRID 706314ノート

反応式

HRID 706314 の反応式
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH3:18][O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1.[Si](C#N)(C)(C)C.[N:37]1([C:42](N2C=CN=C2)=[O:43])C=CN=[CH:38]1>>[CH3:18][O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]2[N:8]([C:9]3[CH:17]=[CH:16][C:12]4[NH:13][CH:14]=[N:15][C:11]=4[CH:10]=3)[C:42](=[O:43])[NH:37][CH2:38]2)=[CH:25][CH:24]=1

参加物

6

反応物 5

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanideHCID 84468TrifluoroacetateHCID 64855604-(2-Methoxyethoxy)benzaldehyde

生成物 1

HCID 1784961085-(4-(2-methoxyethoxy)phenyl)-1-(1H-benzo[d]imidazol-5-yl)imidazolidin-2-one

実験手順

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (1.3 gmg, 9.99 mmol), 4-(2-methoxyethoxy)benzaldehyde (1.5 g, 8.33 mmol), TMSCN (1.64 mL, 16.66 mmol) 10% Pd—C (200 mg), TEA (2.5 mL, 18.40 mmol), di-(imidazol-1-yl)methanone (1.192 g, 7.36 mmol), as described in method 2. The product was purified by means of preparative HPLC.

後処理

  1. customThe product was purified by means of preparative HPLC

出典と根拠

ORDレコード
ord-313b66a7b08449b9aa0dc9c3f7dc27e2
出典データセット
uspto-grants-2015_11
特許番号
US09173885B2

反応ノート

読み込み中…