Trifluoroacetic acid → 3-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-one

HRID 70717ノート

反応式

HRID 70717 の反応式
FC(F)(F)C(O)=O.[CH:8]1([C:11]2[C:12]([O:39]CC3C=CC(OC)=CC=3)=[N:13][C:14]([CH:17]([C:27]3[CH:32]=[CH:31][C:30]([S:33]([CH:36]4[CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:29][CH:28]=3)[O:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[F:26])=[CH:15][CH:16]=2)[CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[CH:8]1([C:11]2[C:12](=[O:39])[NH:13][C:14]([CH:17]([C:27]3[CH:28]=[CH:29][C:30]([S:33]([CH:36]4[CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:31][CH:32]=3)[O:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[F:26])=[CH:15][CH:16]=2)[CH2:9][CH2:10]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 673995783-Cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine

生成物 1

HCID 584523163-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-one収率 74.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Trifluoroacetic acid (50 mg) was added to a solution of 3-cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine (90 mg) in chloroform (5 mL), and the mixture was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100) to give the title compound as a yellow powder (53 mg, 74%).

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100)

出典と根拠

ORDレコード
ord-f6090705c34d44e294452ccad8fe1e87
出典データセット
uspto-grants-2014_09
特許番号
US08822503B2

反応ノート

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