P-Coumaric Acid → HCID 178511829、化合物

HRID 711126

反応式

HRID 711126 の反応式
[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[CH:29]1[C:34](/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38])=[CH:33][CH:32]=[C:31]([OH:40])[CH:30]=1>C(#N)C>[CH:1]1[C:2]([CH2:10][C@@H:11]([NH2:28])[CH2:12][C:13]([N:15]2[CH2:27][C:19]3=[N:20][N:21]=[C:22]([C:23]([F:26])([F:25])[F:24])[N:18]3[CH2:17][CH2:16]2)=[O:14])=[C:3]([F:9])[CH:4]=[C:5]([F:8])[C:6]=1[F:7].[C:37]([O-:39])(=[O:38])/[CH:36]=[CH:35]/[C:34]1[CH:33]=[CH:32][C:31]([OH:40])=[CH:30][CH:29]=1

参加物

4

反応物 2

HCID 637542P-Coumaric AcidHCID 4369359Sitagliptin

生成物 1

HCID 178511829HCID 178511829、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Sitagliptin free base (2.0 gms) and coumaric acid (0.80 gms) were dissolved in acetonitrile (15 ml) at 60° C. to 65° C. and cooled the solution to −10° C. to −5° C. over a period of 6 hours. Precipitated solids were filtered and dried at 50° C. to 55° C. for 6 hours to obtain the title compound. Yield: 1.62 gms.

後処理

  1. temperaturecooled the solution to −10° C. to −5° C. over a period of 6 hours
  2. customPrecipitated solids
  3. filtrationwere filtered
  4. customdried at 50° C. to 55° C. for 6 hours

出典と根拠

ORDレコード
ord-2088f85a537b4efd82a5de1bdb5d899c
出典データセット
uspto-grants-2015_11
特許番号
US09181256B2

関連ノート

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