Ethanol → HCID 71186559、化合物

反応式

C([N:8]1[CH2:11][CH2:10][CH:9]1[C:12]([NH:14][C@H:15]([C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][CH:18]=1)[CH3:16])=[O:13])C1C=CC=CC=1.CCO.C([O-])=O.[NH4+]>[Pd]>[NH:8]1[CH2:11][CH2:10][CH:9]1[C:12]([NH:14][C@H:15]([C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][CH:18]=1)[CH3:16])=[O:13]

参加物

実験手順

To a solution of methyl 4-((1S)-1-(1-benzylazetidine-2-carboxamido)ethyl)benzoate (D76) (98 mg, 0.278 mmol in EtOH (20 ml) Pd/C 10% (90 mg, 0.083 mmol) and ammonium formate (52 mg, 0.83 mmol) were added and the heterogeneous solution was left stirring at RT for 20 hrs. Further addition of Pd/C 10% (90 mg, 0.083 mmol) and ammonium formate (52 mg, 0.83 mmol) was done and the resulting mixture was stirred at RT for 5 hrs. Catalyst was filtered off and the solvent evaporated to afford the title compound (D109) (60 mg).