Trifluoroacetic acid → 1-[(Pyridin-2-yl)methyl]piperazine

HRID 713714

反応式

HRID 713714 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1.FC(F)(F)C(O)=O>ClCCl>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 10062065Tert-butyl 4-(pyridin-2-ylmethyl)piperazine-1-carboxylate

生成物 1

HCID 8087141-[(Pyridin-2-yl)methyl]piperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 0.11 g (0.4 mmol) of the title compound from Step A above in 1 mL dichloromethane and 1 mL trifluoroacetic acid was stirred at ambient temperature for 1 h. All volatiles were removed in vacuo and the crude light brown residue was carried forward without purification. LC/MS: m/z (ES) 178.2 (MH)+.

後処理

  1. customAll volatiles were removed in vacuo
  2. customthe crude light brown residue was carried forward without purification

出典と根拠

ORDレコード
ord-6a88eeb56878449f970f1eca834df1c4
出典データセット
uspto-grants-2015_11
特許番号
US09186354B2

関連ノート

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