Methyl iodide → 2-(Methylthio)-1H-pyrimidin-4-one

HRID 714893

反応式

HRID 714893 の反応式
[OH-].[Na+].[S:3]=[C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][NH:5]1.I[CH3:12]>C(O)(=O)C>[CH3:12][S:3][C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 1269845Thiouracil

生成物 1

HCID 798232-(Methylthio)-1H-pyrimidin-4-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To an aqueous solution (200 mL) of sodium hydroxide (23 g) were added 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (37 g) and iodomethane (20 mL), and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (17 mL), and the precipitate was collected by filtration, and washed with ice water. The residue was dried to give the title compound (28 g).

後処理

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with ice water
  3. customThe residue was dried

出典と根拠

ORDレコード
ord-74fa7b4aec504bbdbd472f003f2699b9
出典データセット
uspto-grants-2015_11
特許番号
US09187453B2

関連ノート

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