Methanol → (S)-3-(hydroxymethyl)-7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3',2'-e]pyrazin-6(6aH)-one

温度

0 °C

In round-bottomed flask, (S)-methyl 6-oxo-6,6a,7,8,9,10-hexahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazine-3-carboxylate (860 mg, 3.29 mmol) was dissolved in Tetrahydrofuran (Volume: 41 mL) to give a clear solution. The solution was cooled to 0° C. and NaH (197 mg, 4.94 mmol) was added. The reaction was allowed to stir at RT for 0.5 hour. The translucent solution was then cooled to −78° C. and LAH was added over two minutes. The reaction temperature was maintained between −30° C. and −20° C. for 3 hours while stirring, then cooled to −78° C. Methanol (3 ml, gas evolution) and water (1 ml) were added. The reaction was stirred at room temperature for 30 minutes. The crude product was added to 400 ml ethyl acetate. Water (100 ml) was added and the mixture stirred for 1 hr. The mixture was filtered through medium frit to remove tan solids which were discarded. The aqueous layer was extracted with ethyl acetate (1×100 mL). The organic fractions were combined, washed once with brine and dried with sodium sulfate and concentrated to yield 743 mg (97%) of the product as a white residue. [M+H] calc'd for C12H15N3O2, 234. found, 234.

1. customto give a clear solution
2. temperatureThe translucent solution was then cooled to −78° C.
3. temperatureThe reaction temperature was maintained between −30° C. and −20° C. for 3 hours
4. stirringwhile stirring
5. temperaturecooled to −78° C
6. stirringThe reaction was stirred at room temperature for 30 minutes
7. stirringthe mixture stirred for 1 hr
8. filtrationThe mixture was filtered through medium frit
9. customto remove tan solids which
10. extractionThe aqueous layer was extracted with ethyl acetate (1×100 mL)
11. washwashed once with brine
12. dry with materialdried with sodium sulfate
13. concentrationconcentrated

ORDレコード

ord-3b0c1989bf0f4b1fa8f530703dce00b4

出典データセット

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09187497B2