Ammonium Chloride → N-(3,4-diaminophenyl)methanesulfonamide

HRID 717320ノート

反応式

HRID 717320 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][C:3]=1[N+:13]([O-])=O.[BH4-].[Na+].[NH4+].[Cl-]>CO.CCOC(C)=O.[Pd]>[NH2:13][C:3]1[CH:4]=[C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:6]=[CH:7][C:2]=1[NH2:1]

参加物

6

反応物 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 1270965376345-45-4

生成物 1

HCID 12709656N-(3,4-diaminophenyl)methanesulfonamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

N-(4-amino-3-nitrophenyl)methanesulfonamide (1.5 g, 6.5 mmol) was dissolved in MeOH/EtOAc(1:1, 160 mL). To the above solution were slowly added 10% Pd/C (110 mg) and NaBH4 (418 mg, 11.0 mmol). The reaction mixture was stirred for 1 h, after which TLC showed absence of starting material. After addition of NH4Cl (400 mg), the reaction mixture was filtered through CELITE. The filtrate was concentrated and the product was used without further purification.

後処理

  1. filtrationthe reaction mixture was filtered through CELITE
  2. concentrationThe filtrate was concentrated
  3. customthe product was used without further purification

出典と根拠

ORDレコード
ord-3684ccedc0ff439f945a34825669fedc
出典データセット
uspto-grants-2015_11
特許番号
US09193717B2

反応ノート

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