Iodoethane → 5-Ethoxy-1-tetralone

HRID 719173ノート

反応式

HRID 719173 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].[OH-].[Na+].[CH2:15](I)[CH3:16]>C(O)C.Cl>[CH2:15]([O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12])[CH3:16]

参加物

6

反応物 3

HCID 6340IodoethaneHCID 14798Sodium HydroxideHCID 1199215-Hydroxy-1-tetralone

生成物 1

HCID 218967975-Ethoxy-1-tetralone

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

A mixture of 5-hydroxy-1-tetralone (2.00 g) and sodium hydroxide (493 mg) was warmed in ethanol (40 mL) to 50° C. Ethyl iodide (3.94 mL) was then added and the reaction mixture was heated at reflux for 16 hours. The reaction mixture was diluted with 2N hydrochloric acid, extracted into ethyl acetate, dried and the solvent removed in vacuo to yield 5-ethoxy-1-tetralone as a white solid (2.06 g)

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 16 hours
  3. extractionextracted into ethyl acetate
  4. customdried
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-b0e0134a1c8b4877b7660496db6f4dc1
出典データセット
uspto-grants-2006_11
特許番号
US07132419B2

反応ノート

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