1,1'-Carbonyldiimidazole → 4'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid (4-dimethylamino-butyl)-amide

Prepared in the same manner as described for example 1. A solution of 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid (0.85 g, 2.33 mmol, 1 eq.) in anhydrous THF was treated with 1,1′-carbonyldiimidazole (0.40 g, 2.45 mmol, 1.05 eq.) and warmed as described. The reaction was allowed to cool and then treated with 4-dimethylaminobutylamine (0.33 g, 2.80 mmol, 1.2 eq.). The reaction was treated as described in example 1 to give a yellow oil. The oil was purified by silica gel flash chromatography using 5% 2M NH3 in methanol in chloroform as the mobile phase. Fractions containing the product were pooled and the solvent removed in vacuo leaving 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid (4-dimethylamino-butyl)-amide (1.06 g, 98% yield) as a light yellow oil.