Diisopropylethylamine → HCID 21882826、化合物

HRID 722136ノート

反応式

HRID 722136 の反応式
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:4]=1[CH2:10]Br.[C:12]1([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14][CH:13]=1.CCN(C(C)C)C(C)C>CC#N>[Br-:1].[F:9][C:5]1[C:4]2[CH2:10][CH:13]3[C:12](=[N+:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH:16]([CH2:2][C:3]=2[CH:8]=[CH:7][CH:6]=1)[CH2:15][CH2:14]3

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 81570Pyrrolidine, 1-(1-cyclopenten-1-yl)-HCID 141116001,2-Bis(bromomethyl)-3-fluorobenzene

生成物 1

HCID 21882826HCID 21882826、化合物収率 19.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

A solution of 1,2-bis-bromomethyl-3-fluoro-benzene (4.4 g, 15.6 mmol) in MeCN (10 ml) was added to stirred solution of 1-cyclopent-1-enyl-pyrrolidine (2.3 ml, 15.6 mmol) and DIPEA (5.4 ml, 31.2 mmol) in MeCN (20 ml). The mixture was stirred at room temperature for 18 hours and then filtered. Washing with cold MeCN afforded an off-white solid 1.02 g (19%). m/z 258 (M+).

後処理

  1. filtrationfiltered
  2. washWashing with cold MeCN

出典と根拠

ORDレコード
ord-c1a7c274bb1e4c4b9fe095679e833898
出典データセット
uspto-grants-2006_11
特許番号
US07138400B2

反応ノート

読み込み中…