2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 178488186、化合物

HRID 722202

反応式

HRID 722202 の反応式
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([C:23]2[NH:27][C:26]([CH3:28])=[N:25][N:24]=2)[CH:20]=[CH:19][C:18]=1[NH2:29]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:29][C:18]1[CH:19]=[CH:20][C:21]([C:23]2[NH:27][C:26]([CH3:28])=[N:25][N:24]=2)=[CH:22][C:17]=1[O:16][CH3:15])=[O:8])=[O:5]

参加物

4

反応物 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 178488184HCID 178488184、化合物

生成物 1

HCID 178488186HCID 178488186、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 30 mg of 2-methoxy-4-(5-methyl-4H-[1,2,4]triazol-3-yl)phenylamine in 3 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was then filtered off with suction, stirred with isopropanol and dried under reduced pressure.

後処理

  1. filtrationThe solid was then filtered off with suction
  2. stirringstirred with isopropanol
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-9d63ce9c4ae741549cc6f9bc5d723dc6
出典データセット
uspto-grants-2006_11
特許番号
US07138414B2

関連ノート

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