2-(3-Methyl-5-(4-nitrophenyl)-4H-1,2,4-triazol-4-yl)benzoic acid → 2-(3-(4-Aminophenyl)-5-methyl-4H-1,2,4-triazol-4-yl)benzoic acid
反応式
[CH3:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])[C:5]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=2)=[N:4][N:3]=1>O1CCCC1.[Pd]>[NH2:22][C:19]1[CH:18]=[CH:17][C:16]([C:5]2[N:6]([C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[C:9]([OH:11])=[O:10])[C:2]([CH3:1])=[N:3][N:4]=2)=[CH:21][CH:20]=1参加物
4
実験手順
was prepared by hydrogenating 270 mg of 2-[3-methyl-5-(4-nitrophenyl)-[1,2,4]triazol-4-yl]benzoic acid in the presence of Pd/C in tetrahydrofuran and purified by column chromatography (silica gel, solvent: 95:5 dichloromethane:methanol).
後処理
- custompurified by column chromatography (silica gel, solvent: 95:5 dichloromethane:methanol)
出典と根拠
- ORDレコード
- ord-b495dac1305d4104b8ac2d22b55df57e
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07138414B2
反応ノート
読み込み中…