Dimethylformamide → 3-Methyl-2-phenylvaleryl chloride

HRID 722712

反応式

HRID 722712 の反応式
[CH3:1][CH:2]([CH2:13][CH3:14])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](O)=[O:5].CN(C)C=O.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[CH3:1][CH:2]([CH2:13][CH3:14])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([Cl:23])=[O:5]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 2959613-Methyl-2-phenylpentanoic acid

生成物 1

HCID 218860263-Methyl-2-phenylvaleryl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 3-methyl-2-phenylvaleric acid (1.23 g; 6.2 mmol) and a catalytic amount of dry dimethylformamide (ca. 20 μL) in 5 mL of dry methylene chloride under nitrogen at room temperature was added oxalyl chloride (4.8 mL of 2.0 M solution in methylene chloride) dropwise. After 45 minutes, the mixture was concentrated in vacuo and used immediately for Step 2.

後処理

  1. concentrationthe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-2a4c185e9436403caedbe74555c00be8
出典データセット
uspto-grants-2006_11
特許番号
US07138529B2

関連ノート

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