Triethylamine → 2-Cyano-3-fluoropyridine

HRID 723717ノート

反応式

HRID 723717 の反応式
[F:1][C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][CH:7]=1.C[Si]([C:13]#[N:14])(C)C.C(N(CC)CC)C>C(#N)C>[C:13]([C:3]1[C:2]([F:1])=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:14]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 82115Trimethylsilyl cyanideHCID 123084Pyridine, 3-fluoro-, 1-oxide

生成物 1

HCID 70604082-Cyano-3-fluoropyridine収率 70%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

3-Fluoropyridine-1-oxide (10.0g, 88.4 mmol), trimethylsilylcyanide (26.32g, 265.3 mmol), and triethylamine (17.89g, 177 mmol) were reacted in 90 mL of acetonitrile utilizing the procedure described in example 762B. Purification of the crude by silica gel chomatography using CH2Cl2 as eluent gives compound 771B (7.5g, 70%) as a light yellow solid.

後処理

  1. customPurification of the crude by silica gel chomatography

出典と根拠

ORDレコード
ord-08b764105c2d4d27b5ea0492d2a71faa
出典データセット
uspto-grants-2006_11
特許番号
US07141578B2

反応ノート

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