tert-Butanol → tert-Butyl (1-(4-bromophenyl)cyclopropyl)carbamate

To the solution of 1-(4-bromophenyl)cyclopropanecarboxylic acid (40 g, 165 mmol, available from Amatek Chemical #AC-0350) in toluene (800 ml), in the presence of activated molecular sieves (15 g), N,N-diisopropylethylamine (27.5 g, 497 mmol), Diphenylphosphoryl azide (54.7 g, 215 mmol) and tert-Butanol (380 ml) were added. The resulting mixture was refluxed 5 hours. The mixture was cooled to room temperature and the solvents evaporated in vacuo. The residue was dissolved in ethyl acetate (200 ml) and washed with 5% citric acid (200 ml), aqueous NaHCO3 (200 ml) and brine (200 ml). Collected organics after drying over Na2SO4 and solvent evaporation afforded a crude residue which was purified by flash chromatography on silica gel eluting with a mixture petroleum ether/ethyl acetate 4:1. Collected fractions after solvent evaporation afforded the title compound (D4) (23.0 g) as a solid.

1. temperatureThe resulting mixture was refluxed 5 hours
2. customthe solvents evaporated in vacuo
3. dissolutionThe residue was dissolved in ethyl acetate (200 ml)
4. washwashed with 5% citric acid (200 ml), aqueous NaHCO3 (200 ml) and brine (200 ml)
5. dry with materialCollected organics after drying over Na2SO4 and solvent evaporation
6. customafforded a crude residue which
7. customwas purified by flash chromatography on silica gel eluting with a mixture petroleum ether/ethyl acetate 4:1
8. customCollected fractions after solvent evaporation

ORDレコード

ord-00e484cfb6864369835e2c1a80c36aa5

出典データセット

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08828987B2