Hydrogen Bromide → HCID 178520414、化合物
反応式
C([N:20]1[CH:24]=[C:23]([C:25](=[O:28])[CH:26]=[CH2:27])[N:22]=[CH:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[BrH:29].C(OC(C)C)(C)C>C(O)(=O)C>[Br:29][CH2:27][CH2:26][C:25]([C:23]1[N:22]=[CH:21][NH:20][CH:24]=1)=[O:28]参加物
5
反応条件
- 温度
- 10 °C
実験手順
1-(1-Trityl-1H-imidazol-4-yl)-2-propen-1-one (29.0 g) was dissolved in acetic acid (130 ml) and the mixture was cooled to 10° C. A 25% solution of hydrogen bromide in acetic acid (100 ml) was added and the mixture was stirred at room temperature for 2 h. Isopropyl ether was added to the reaction mixture and the precipitated crystals were collected by filtration and washed with diisopropyl ether to give the title compound (22.3 g) as a pale yellow powder.
後処理
- filtrationthe precipitated crystals were collected by filtration
- washwashed with diisopropyl ether
出典と根拠
- ORDレコード
- ord-a403f1573a534468a7c9b17fe82ce75d
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07141598B2
反応ノート
読み込み中…