2-Aminophenol → 2-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[Br:9][C:10]([CH3:15])([CH3:14])[C:11](Br)=[O:12].C(N(CC)CC)C>C(Cl)Cl>[Br:9][C:10]([CH3:15])([CH3:14])[C:11]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8])=[O:12]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a stirred solution of 2-aminophenol (10 g, 9.2 mmol) in DCM (92 mL) at 0° C. was added 2-bromoisobutyryl bromide (11.4 mL, 9.17 mmol) followed by triethyl amine (12.7 mL, 9.2 mmol) and stirred the reaction mixture at 0° C. for 4 h. Reaction mixture was diluted with DCM 100 mL and then washed with water 100 mL dried over sodium sulfate, concentrated on rotavap to give 2-Bromo-N-(2-hydroxy-phenyl)-2-methyl-propionamide (21.8 g) brown solid which was used for next reaction without purification
後処理
- customReaction mixture
- washwashed with water 100 mL
- dry with materialdried over sodium sulfate
- concentrationconcentrated on rotavap
出典と根拠
- ORDレコード
- ord-f70754058db14c05b3f9a06965862770
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08828951B2
反応ノート
読み込み中…