2-Aminophenol → 2-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide

HRID 72561

反応式

HRID 72561 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[Br:9][C:10]([CH3:15])([CH3:14])[C:11](Br)=[O:12].C(N(CC)CC)C>C(Cl)Cl>[Br:9][C:10]([CH3:15])([CH3:14])[C:11]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8])=[O:12]

参加物

5

反応物 3

HCID 58012-AminophenolHCID 8471TriethylamineHCID 886852-Bromo-2-methylpropionyl bromide

生成物 1

HCID 146849852-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide収率 921%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To a stirred solution of 2-aminophenol (10 g, 9.2 mmol) in DCM (92 mL) at 0° C. was added 2-bromoisobutyryl bromide (11.4 mL, 9.17 mmol) followed by triethyl amine (12.7 mL, 9.2 mmol) and stirred the reaction mixture at 0° C. for 4 h. Reaction mixture was diluted with DCM 100 mL and then washed with water 100 mL dried over sodium sulfate, concentrated on rotavap to give 2-Bromo-N-(2-hydroxy-phenyl)-2-methyl-propionamide (21.8 g) brown solid which was used for next reaction without purification

後処理

  1. customReaction mixture
  2. washwashed with water 100 mL
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated on rotavap

出典と根拠

ORDレコード
ord-f70754058db14c05b3f9a06965862770
出典データセット
uspto-grants-2014_09
特許番号
US08828951B2

関連ノート

読み込み中…