4-fluoro-N-(4-nitrophenyl)benzamide → N-(4-Aminophenyl)-4-fluorobenzamide

HRID 726337ノート

反応式

HRID 726337 の反応式
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1.[H][H]>O1CCCC1.[Pt]>[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 39484284-fluoro-N-(4-nitrophenyl)benzamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10988055N-(4-Aminophenyl)-4-fluorobenzamide収率 98.7%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 56.6 gm (0.217 mole) 4-(4-fluorobenz-oyl)aminonitrobenzene in 875 mL tetrahydrofuran were added 5.7 gm 5% platinum on carbon. The reaction mixture was hydrogenated at room temperature for 18 hours at initial hydrogen pressure of 60 p.s.i. The reaction mixture was then filtered and the filtrate concentrated under reduced pressure to give 49.3 gm (98.5%) of the desired compound.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ccf2297eda5a41cc90426f03eaece458
出典データセット
uspto-grants-1998_01
特許番号
US05708187

反応ノート

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