Water → 3-(3-(3-Pentynyloxy)-1,2,5-thiadiazol-4-yl)pyridine

HRID 727310

反応式

HRID 727310 の反応式
[CH2:1]([OH:6])[CH2:2][C:3]#[C:4][CH3:5].[H-].[Na+].Cl[C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1.O>O1CCCC1>[CH2:1]([O:6][C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1)[CH2:2][C:3]#[C:4][CH3:5]

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 662953-Pentyn-1-olHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

生成物 1

HCID 190752603-(3-(3-Pentynyloxy)-1,2,5-thiadiazol-4-yl)pyridine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 3-pentyn-1-ol (750 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

後処理

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-893629a4c5ba4ecfae3dec49f2ce7bde
出典データセット
uspto-grants-1998_01
特許番号
US05712297

関連ノート

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