Water → β-AMinoMethyl-benzeneethanol

HRID 727942

反応式

HRID 727942 の反応式
[NH2:1][CH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:4]C(O)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH2:20].[OH-].[Na+]>C(COC)OC>[NH2:1][CH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:4][OH:20]

参加物

6

反応物 4

HCID 962WaterHCID 14113PhenibutHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 11286566β-AMinoMethyl-benzeneethanol

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

For the preparation of the alcohols VI used in Examples (3a) and (3b). 10 g of 3-amino-2-phenylpropanecarboxylic acid in 150 ml of monoglyme were stirred with 3 g of LiAlH4 for 20 hrs. Then, 12 ml of water and 3 ml of 10% sodium hydroxide solution were slowly added thereto. The mixture was filtered and the filtrate was again evaporated with toluene. There was obtained 8.4 g of β-(aminomethyl)-phenethyl alcohol.

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was again evaporated with toluene

出典と根拠

ORDレコード
ord-94cfd474d910450e9c00447414ac647c
出典データセット
uspto-grants-1991_09
特許番号
US05045567

関連ノート

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