Water → 1,2-Diphenylethyl-N-methylamine

HRID 728317

反応式

HRID 728317 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([NH:12][CH:13]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(OCC)=O.O.[OH-].[Na+]>O1CCCC1>[CH3:7][NH:12][CH:13]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 234956Ethyl (1,2-diphenylethyl)carbamateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 1109861,2-Diphenylethyl-N-methylamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a stirred suspension of lithium aluminum hydride (12.4 g, 0.32 mol) in 300 ml of tetrahydrofuran at 0° C. under nitrogen was added dropwise a solution of N-carboethoxy-1,2-diphenylethylamine (35.0 g, 0.13 mol) in 200 ml of tetrahydrofuran. The mixture was heated to reflux for 8 hours. The mixture was cooled in an ice-water bath and water (13 ml), 15% NaOH (13 ml) and water (39 ml) were carefully added to the mixture. The mixture was warmed to ambient temperature and the precipitated salts were removed by filtration through celite. Removal of solvent gave N-methyl-1,2-diphenylethylamine, 26.8 g as a colorless oil.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 8 hours
  3. temperatureThe mixture was cooled in an ice-water bath
  4. customthe precipitated salts were removed by filtration through celite
  5. customRemoval of solvent

出典と根拠

ORDレコード
ord-3138c27f06f949bdb1d39ca69aa14bb2
出典データセット
uspto-grants-1991_09
特許番号
US05047541

関連ノート

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