Triethylamine → N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide

HRID 728814

反応式

HRID 728814 の反応式
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:26](Cl)(=[O:29])[CH2:27][CH3:28]>C1COCC1>[C:13]1([CH2:12][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10][NH:11][C:26](=[O:29])[CH2:27][CH3:28])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 6394114N1,N1-Dibenzylethane-1,2-diamine

生成物 1

HCID 54327882N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

To a chilled solution of 5.0 g (21 mmol) N,N-dibenzylethylenediamine and 30mL (21 mmol) triethylamine in 20 mL THF is added 1.8 mL (21 mmol) propionylchloride, dropwise. The temperature of the reaction mixture is maintained below 0° C. during addition. The reaction mixture is stirred for 30minutes at 0° C. After this time, the reaction mixture is filtered and the solvents are evaporated to give the product which can be purified via column chromatography.

後処理

  1. temperatureThe temperature of the reaction mixture is maintained below 0° C. during addition
  2. filtrationAfter this time, the reaction mixture is filtered
  3. customthe solvents are evaporated
  4. customto give the product which
  5. customcan be purified via column chromatography

出典と根拠

ORDレコード
ord-6c796ddafef5454ba34e40ccd9db3930
出典データセット
uspto-grants-1991_09
特許番号
US05051423

関連ノート

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