Chlorosulfonic acid → HCID 14998830、化合物

HRID 728956

反応式

HRID 728956 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[C:6]1([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[N:12]1([C:6]2[CH:11]=[CH:10][C:9]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:8][CH:7]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 815951-Phenylimidazole

生成物 1

HCID 14998830HCID 14998830、化合物

実験手順

To chlorosulfonic acid cooled to 0° C. in an ice bath is added portionwise 1-phenyl-1H-imidazole. Monitor the progress of the reaction bythin-layer chromatography. When the reaction is complete, quench the mixture on ice. Saturated aqueous NaHCO3 is added until the solution is no longer acidic. Extract the mixture with CH2Cl2. Dry the organic layer over anhydrous Na2SO4 and remove the solvent in vacuo to obtain the title compound.

後処理

  1. customquench the mixture on ice
  2. additionSaturated aqueous NaHCO3 is added until the solution
  3. extractionExtract the mixture with CH2Cl2
  4. dry with materialDry the organic layer over anhydrous Na2SO4
  5. customremove the solvent in vacuo

出典と根拠

ORDレコード
ord-6cc879f52e8e41ef9074507710849770
出典データセット
uspto-grants-1991_09
特許番号
US05051422

関連ノート

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