Sodium Iodide → 2-[4-[5-(3-Methylisoxazol-5-yl)pentoxy]phenyl]-1,3,4-oxadiazole

HRID 728991ノート

反応式

HRID 728991 の反応式
[O:1]1[CH:5]=[N:4][N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[O:23][N:22]=[C:21]([CH3:24])[CH:20]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C(#N)C>[CH3:24][C:21]1[CH:20]=[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][O:12][C:9]2[CH:10]=[CH:11][C:6]([C:2]3[O:1][CH:5]=[N:4][N:3]=3)=[CH:7][CH:8]=2)[O:23][N:22]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 7147704-(1,3,4-Oxadiazol-2-yl)phenolHCID 135440465-(5-Bromopentyl)-3-methylisoxazole

生成物 1

HCID 148360152-[4-[5-(3-Methylisoxazol-5-yl)pentoxy]phenyl]-1,3,4-oxadiazole収率 40.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 23.6 g 4-(1,3,4-oxadiazolyl)phenol (U.S. Pat. No. 4,218,458, Example XIX), 35 g 5-(5-bromopentyl)-3-methylisoxazole and 40 g milled potassium carbonate in 1.5 liters acetonitrile under nitrogen was heated to reflux. A catalytic amount of sodium iodide was added and refluxing continued for 4 hrs. The reaction mixture was filtered and concentrated toa solid residue. The latter was dissolved in ethyl acetate and the solutionwashed with water and saturated sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. The residue was recrystallized from triethylamine to give 18.5 g 3-methyl-5-{5-[4-(1,3,4-oxadiazol-2-yl)phenoxy]pentyl}isoxazole, white needles, m.p. 84°-86° C.

後処理

  1. temperaturewas heated to reflux
  2. temperaturerefluxing
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated toa solid residue
  5. dissolutionThe latter was dissolved in ethyl acetate
  6. dry with materialthe solutionwashed with water and saturated sodium chloride solution, dried over magnesium sulfate
  7. concentrationconcentrated in vacuo
  8. customThe residue was recrystallized from triethylamine

出典と根拠

ORDレコード
ord-83aa13532bc040c6902ae98dbfdfe7f3
出典データセット
uspto-grants-1991_09
特許番号
US05051437

反応ノート

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