N-bromobutanimide → HCID 66868795、化合物

HRID 729995

反応式

HRID 729995 の反応式
[Br:1]N1C(=O)CCC1=O.[CH2:9]([N:16]1[CH:20]=[CH:19][N:18]=[C:17]1[CH3:21])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)(Cl)Cl>[CH2:9]([N:16]1[C:20]([Br:1])=[CH:19][N:18]=[C:17]1[CH3:21])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 836991H-Imidazole, 2-methyl-1-(phenylmethyl)-

生成物 1

HCID 66868795HCID 66868795、化合物収率 84.2%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Add N-bromosuccinimide (7.85 g, 44 mmol) to a solution of 1-benzyl-2-methyl-1H-imidazole (8.0 g, 46 mmol) in chloroform (200 mL) and stir for 6 h. Wash with saturated aqueous sodium hydrogen carbonate and saturated aqueous NaCl, dry over MgSO4, and filter through a pad of silica gel. Concentrate filtrate and suspend the residue in diethyl ether (600 mL), heat to reflux, and filter hot. Concentrate ether filtrate to give the title compound as a tan solid (9.3 g).

後処理

  1. washWash with saturated aqueous sodium hydrogen carbonate and saturated aqueous NaCl
  2. dry with materialdry over MgSO4
  3. filtrationfilter through a pad of silica gel
  4. temperatureheat
  5. temperatureto reflux
  6. filtrationfilter hot

出典と根拠

ORDレコード
ord-42c98c3babcb49f8bfa577afcb1884f8
出典データセット
uspto-grants-2009_09
特許番号
US07582652B2

関連ノート

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