1,1'-Carbonyldiimidazole → 5-Trifluoromethyl-1,3-dihydro-benzimidazol-2-one

HRID 730700

反応式

HRID 730700 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([NH2:10])[CH:4]=1.[C:13](N1C=CN=C1)(N1C=CN=C1)=[O:14]>C1COCC1>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:8]=[CH:7][C:6]2[NH:9][C:13](=[O:14])[NH:10][C:5]=2[CH:4]=1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 5208224-Trifluoromethyl-1,2-phenylenediamine

生成物 1

HCID 118201505-Trifluoromethyl-1,3-dihydro-benzimidazol-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-trifluoromethyl-1,2-phenylenediamine (8.8 g, 50 mmol, Lancaster) and 1,1′-carbonyldiimidazole (9.0 g, 55 mmol, Aldrich) in THF (50 mL) was stirred at room temperature for 16 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with EtOAc to give the title compound. MS (ESI, pos. ion) m/z: 203 (M+1).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by silica gel chromatography
  3. washeluting with EtOAc

出典と根拠

ORDレコード
ord-04e9bb371a82400bb05f9ca6233dd47e
出典データセット
uspto-grants-2009_09
特許番号
US07582761B2

関連ノート

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