Hydrochloric Acid → 2-sec-Butylamino-6-methanesulfonyloxy-isonicotinic acid
反応式
[OH-].[Li+].C[O:4][C:5](=[O:22])[C:6]1[CH:11]=[C:10]([O:12][S:13]([CH3:16])(=[O:15])=[O:14])[N:9]=[C:8]([NH:17][CH:18]([CH2:20][CH3:21])[CH3:19])[CH:7]=1.Cl>C1COCC1>[CH:18]([NH:17][C:8]1[CH:7]=[C:6]([CH:11]=[C:10]([O:12][S:13]([CH3:16])(=[O:15])=[O:14])[N:9]=1)[C:5]([OH:22])=[O:4])([CH2:20][CH3:21])[CH3:19]参加物
5
実験手順
Add 1 N lithium hydroxide (2 mL) to a solution of 2-sec-butylamino-6-methanesulfonyloxy-isonicotinic acid methyl ester (235 mg, 0.743 mmol) in THF (15 mL) at 0° C. Warm to room temperature and stir for 12 h. Acidify with 5% aqueous HCl to about pH=3, extract with ethyl acetate, dry (magnesium sulfate), and concentrate to give the title compound.
後処理
- extractionextract with ethyl acetate
- dry with materialdry (magnesium sulfate)
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-a4517930dfb84140bbbad457cb2a8c40
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07585885B2
反応ノート
読み込み中…