Aniline → N-(3,4-Dichloro-phenyl)-2-phenylamino-acetamide
反応式
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1)=[O:4].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(C(C)C)C(C)C)C>C1COCC1>[Cl:13][C:8]1[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:11]=[CH:10][C:9]=1[Cl:12]参加物
5
実験手順
To 2-bromo-N-(3,4-dichloro-phenyl)-acetamide (2 g) in THF (80 mL) was added aniline (41 mg) and N-ethyldiisopropylamine and the reaction mixture was stirred over night at reflux. The precipitated salt was then filtered off and the filtrate was then concentrated in vacuo. The residue was then purified by column chromatography to give the title compound as a light brown solid (1.3 g, mp=110-112° C.).
後処理
- temperatureat reflux
- filtrationThe precipitated salt was then filtered off
- concentrationthe filtrate was then concentrated in vacuo
- customThe residue was then purified by column chromatography
出典と根拠
- ORDレコード
- ord-4fb9c061612d47e7be6cf8c1001922d4
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07589089B2
反応ノート
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