tert-Butyl mercaptan → HCID 57842722、化合物

HRID 735511ノート

反応式

HRID 735511 の反応式
C([S:3]([C:6]1[CH:13]=CC([N+]([O-])=O)=C[C:7]=1C#N)(=[O:5])=[O:4])C.F[C:18]1[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][C:19]=1[C:20]#[N:21].[CH3:29]C(S)(C)C.C1C=C(Cl)C=C(C(OO)=O)C=1>>[C:6]([S:3]([C:18]1[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][C:19]=1[C:20]#[N:21])(=[O:5])=[O:4])([CH3:13])([CH3:29])[CH3:7]

参加物

5

反応物 4

HCID 6387tert-Butyl mercaptanHCID 70297m-Chloroperbenzoic acidHCID 5194172-Fluoro-5-nitrobenzonitrileHCID 574481822-Ethylsulfonyl-5-nitrobenzonitrile

生成物 1

HCID 57842722HCID 57842722、化合物収率 88%

実験手順

Using a procedure analogous to that used to prepare 6A, 2-fluoro-5-nitrobenzonitrile (2.50 g, 15.6 mmol) was reacted with tert-butylthiol and oxidized with mCPBA to afford 10A (3.14 g, 88%) as a white solid. 1H NMR (400 MHz, CDCl3) δ 1.45 (s, 9 H), 7.88 (d, J=8.79 Hz, 1 H), 8.37 (dd, J=8.35, 2.64 Hz, 1 H), 8.55 (d, J=2.64 Hz, 1 H).

出典と根拠

ORDレコード
ord-366e55aa010640e893c848d56b0916f7
出典データセット
uspto-grants-2009_09
特許番号
US07592331B2

反応ノート

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