Ammonium formate → 2-(1,2-Diphenyl-ethyl)-morpholine
反応式
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd]>[C:22]1([CH:14]([CH:10]2[O:11][CH2:12][CH2:13][NH:8][CH2:9]2)[CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1参加物
4
実験手順
To a methanolic solution of 4-Benzyl-2-(1,2-diphenyl-vinyl)-morpholine (4.9 g, 13.9 mmol) is added ammonium formate (14 g, 222.2 mmol) and 10% Pd—C (5 g). The reaction is stirred under nitrogen and heated at reflux for 30 min then cooled to room temperature and filtered through Celite®. The filtrate is concentrated under reduced pressure and the residue is taken up in methanol and purified by cationic ion exchange resin SCX-2® chromatography. The purified residue (2.9 g, 80%) comprises a 3:1 ratio of diastereoisomers.