Ammonium → 4-chloro-1H-pyrrole-2-carboxamide
反応式
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[NH4+:13]>C1COCC1>[Cl:10][C:8]1[CH:9]=[C:5]([C:3]([NH2:13])=[O:4])[NH:6][CH:7]=1参加物
4
実験手順
A solution of 2,2,2-trichloro-1-(4-chloro-1H-Pyrrol-2-yl)ethanone (14.0 g, 56.7 mmol) in THF (100 mL) was bubbled with ammonium gas for 2 h at room temperature. TLC analysis indicated that there was complete conversion of starting material. The reaction mixture was concentrated in vacuo to yield 7.5 g of the above compound (51.88 mmol, yield 92%). 1H-NMR (Acetone-d6) δ 10.92 (br s, 1H), 7.21 (br s, 1H), 7.02 (s, 1H), 6.84 (s, 1H), 6.57 (br s, 1H).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-b8bc12b6e8904d4c98cd4a08ecec8f0b
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829185B2
反応ノート
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