HCID 10171428、化合物 → 2-[(4S)-2,2-Dimethyl-1,3-dioxan-4-yl]-2-methylheptan-3-one

HRID 736852ノート

反応式

HRID 736852 の反応式
[CH3:1][C:2]([C@@H:10]1[CH2:15][CH2:14][O:13][C:12]([CH3:17])([CH3:16])[O:11]1)([C:4](=[O:9])[CH2:5][CH2:6][CH:7]=[CH2:8])[CH3:3]>C1COCC1.[Pd]>[CH3:3][C:2]([C@@H:10]1[CH2:15][CH2:14][O:13][C:12]([CH3:16])([CH3:17])[O:11]1)([C:4](=[O:9])[CH2:5][CH2:6][CH2:7][CH3:8])[CH3:1]

参加物

4

反応物 1

HCID 10171428HCID 10171428、化合物

生成物 1

HCID 673878332-[(4S)-2,2-Dimethyl-1,3-dioxan-4-yl]-2-methylheptan-3-one収率 87%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

24 g (0.1 mol) of (4S)-4-(2-methyl-3-oxo-hept-6-en-2-yl)-2,2-dimethyl-[1,3]dioxane from Example 17 is dissolved in 480 ml of THF. At room temperature, 4.8 g of palladium on carbon (10%) is added. It is hydrogenated at 10 bar of hydrogen for 2 hours until hydrogen absorption is completed. The catalyst is suctioned off, rewashed with THF, and the product is distilled at 95° C./1 mbar. 21 g of product (87% of theory) is obtained.

後処理

  1. customIt is hydrogenated at 10 bar of hydrogen for 2 hours until hydrogen absorption
  2. distillationthe product is distilled at 95° C./1 mbar

出典と根拠

ORDレコード
ord-2da4f7788d3f43a2b009dcd467fcff67
出典データセット
uspto-grants-2009_09
特許番号
US07595418B2

反応ノート

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