Sodium Hydroxide → 5-ethyl-2,3-dihydro-1H-indole
反応式
C1(S([N:10]2[C:18]3[C:13](=[CH:14][C:15]([CH2:19][CH3:20])=[CH:16][CH:17]=3)[CH2:12][CH2:11]2)(=O)=O)C=CC=CC=1.[OH-].[Na+]>Br>[CH2:19]([C:15]1[CH:14]=[C:13]2[C:18](=[CH:17][CH:16]=1)[NH:10][CH2:11][CH2:12]2)[CH3:20]参加物
4
実験手順
A mixture of 1-benzenesulfonyl-5-ethyl-2,3-dihydro-1H-indole (15 g, 0.05 mol) in HBr (48%, 162 mL) was heated at reflux for 6 h. The mixture was basified with sat. NaOH solution to pH 9 and extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give 5-ethyl-2,3-dihydro-1H-indole (2.5 g, 32%).
後処理
- temperaturewas heated
- temperatureat reflux for 6 h
- extractionextracted with ethyl acetate
- washThe organic layer was washed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated under reduced pressure
- customThe residue was purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-2a92c40e07ad45bfada1cd9663177e5f
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829204B2
反応ノート
読み込み中…