Pamidronic Acid → Alendronic Acid

HRID 74141

反応式

HRID 74141 の反応式
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2]N.C[CH2:15][N:16](CC)CC>O>[CH2:2]([CH2:15][NH2:16])[CH2:1][C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5]

参加物

4

反応物 2

HCID 4674Pamidronic AcidHCID 8471Triethylamine

生成物 1

HCID 2088Alendronic Acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.

後処理

  1. customSubsequently, the H2O was removed in the vacuum
  2. customThe product obtained
  3. customwas purified by means of HPLC

出典と根拠

ORDレコード
ord-63709912d71b4b3b8f382421cafd90e3
出典データセット
uspto-grants-2014_09
特許番号
US08829233B2

関連ノート

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