Pamidronic Acid → Alendronic Acid
反応式
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2]N.C[CH2:15][N:16](CC)CC>O>[CH2:2]([CH2:15][NH2:16])[CH2:1][C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5]参加物
4
実験手順
The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.
後処理
- customSubsequently, the H2O was removed in the vacuum
- customThe product obtained
- customwas purified by means of HPLC
出典と根拠
- ORDレコード
- ord-63709912d71b4b3b8f382421cafd90e3
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829233B2
反応ノート
読み込み中…