Methanol → 5-(Benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline

HRID 74186

反応式

HRID 74186 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[CH:12][C:13](C2CCOCC2)=[C:14]([N+:16]([O-])=O)[CH:15]=1.[CH3:25][OH:26]>C1COCC1.[Pd]>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[CH:12][C:13]([NH:3][CH:4]2[CH2:5][CH2:6][O:26][CH2:25][CH2:9]2)=[C:14]([CH:15]=1)[NH2:16]

参加物

5

反応物 2

HCID 887MethanolHCID 674981085-(Benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)nitrobenzene

生成物 1

HCID 674988065-(Benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline収率 89.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

5-(Benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)nitrobenzene (see Working Example 20-1) (1.00 g, 0.76 mol) was dissolved in a solvent mixture of THF (50 mL) and methanol (50 mL), and Pd/C (5%, wet, 0.5 g) was added to carry out a hydrogenation reaction. After being stirred overnight at room temperature, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to yield the title compound (812 mg, 89.1%) as a gray solid.

後処理

  1. additionwas added
  2. customa hydrogenation reaction
  3. customthe catalyst was removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-db448fdc435e4d0a9b8ec2680e8c8fa4
出典データセット
uspto-grants-2014_09
特許番号
US08829035B2

関連ノート

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