1-Phenylpiperazine → 1-[2-(4-Phenylbutyl)phenoxy]-3-(4-phenylpiperazin-1-yl)-2-propanol
反応式
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22][C:23]2[CH:33]=[CH:32][CH:31]=[CH:30][C:24]=2[O:25][CH2:26][CH:27]2[CH2:29][O:28]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(#N)C>[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22][C:23]2[CH:33]=[CH:32][CH:31]=[CH:30][C:24]=2[O:25][CH2:26][CH:27]([OH:28])[CH2:29][N:10]2[CH2:11][CH2:12][N:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:8][CH2:9]2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
3.89 g of N-phenylpiperazine were added to a solution of 1.69 g of 2-[2-(4-phenylbutyl)phenoxymethyl]oxirane [prepared as described in Example 1(a)] in 30 ml of acetonitrile, and the resulting mixture was stirred at 50° C. for 3 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by column chromatography through silica gel, using a 2:3 by volume mixture of ethyl acetate and hexane as the eluent, to give 920 mg (yield 34%) of the title compound as a colorless oil.