Benzenemethanol, 2-(phenylmethoxy)- → 1-(Benzyloxy)-2-(chloromethyl)benzene

HRID 743379

反応式

HRID 743379 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:19])=O>O1CCCC1.C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][Cl:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 18811Benzenemethanol, 2-(phenylmethoxy)-HCID 24386Thionyl Chloride

生成物 1

HCID 5635071-(Benzyloxy)-2-(chloromethyl)benzene

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The whole of the 2-benzyloxybenzyl alcohol thus obtained was dissolved in 500 ml of tetrahydrofuran, and 85 ml of thionyl chloride were added dropwise, whilst ice-cooling, to the resulting solution. The reaction mixture was then allowed to stand overnight at room temperature, after which it was concentrated by evaporation under reduced pressure to give a dark colored oil. This product was dissolved in toluene, and the solution was decolorized by treating it with silica gel for chromatography followed by filtration. The filtrate was concentrated by evaporation under reduced pressure to give 2-benzyloxybenzyl chloride as a yellow oil, which was used in the following reaction without further purification.

後処理

  1. temperaturecooling, to the resulting solution
  2. concentrationafter which it was concentrated by evaporation under reduced pressure
  3. customto give a dark colored oil
  4. additionby treating it with silica gel for chromatography
  5. filtrationfollowed by filtration
  6. concentrationThe filtrate was concentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-de01410fa79f49dd8e2a4f0cc6602f7b
出典データセット
uspto-grants-1996_09
特許番号
US05556864

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