4-Toluenesulfonyl chloride → 4,4-Dimethyl-2-(4'-p-toluenesulfonyloxymethylbiphenyl-2-yl)oxazoline

HRID 743756ノート

反応式

HRID 743756 の反応式
[H-].[Na+].[CH3:3][C:4]1([CH3:23])[CH2:8][O:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[CH:20]=[CH:19][C:18]([CH2:21][OH:22])=[CH:17][CH:16]=2)=[N:5]1.[C:24]1([CH3:34])[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1.[Cl-].[NH4+]>O1CCCC1>[CH3:3][C:4]1([CH3:23])[CH2:8][O:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[CH:16]=[CH:17][C:18]([CH2:21][O:22][S:30]([C:27]3[CH:28]=[CH:29][C:24]([CH3:34])=[CH:25][CH:26]=3)(=[O:32])=[O:31])=[CH:19][CH:20]=2)=[N:5]1

参加物

6

反応物 4

HCID 73974-Toluenesulfonyl chlorideHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 110658764,4-Dimethyl-2-(4'hydroxymethylbiphenyl-2-yl)oxazoline

生成物 1

HCID 153808794,4-Dimethyl-2-(4'-p-toluenesulfonyloxymethylbiphenyl-2-yl)oxazoline収率 55%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

0.34 g (8.5 mmol) of a 60% oily sodium hydride was suspended in tetrahydrofuran (20 ml). A solution of 2.0 g (7.1 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline in tetrahydrofuran (30 ml) was dropwise added thereto at room temperature, followed by further stirring at room temperature for one hour. After the reaction liquid was cooled with ice, a solution of 1.6 g (8.4 mmol) of p-toluenesulfonyl chloride in tetrahydrofuran (20 ml) was dropwise added thereto. After stirring for 3 hours as such, the reaction liquid was poured into a saturated aqueous solution of ammonium chloride, followed by the extraction with chloroform. After washing with water and drying, vacuum concentration was conducted. The residue was purified by silica gel column chromatography (a n-hexane/ethyl acetate system) to give 1.7 g of the title compound as an oil (yield 55%).

後処理

  1. customat room temperature
  2. customAfter the reaction liquid
  3. temperaturewas cooled with ice
  4. stirringAfter stirring for 3 hours as such,
  5. customthe reaction liquid
  6. extractionfollowed by the extraction with chloroform
  7. washAfter washing with water
  8. customdrying
  9. concentrationvacuum concentration
  10. customThe residue was purified by silica gel column chromatography (a n-hexane/ethyl acetate system)

出典と根拠

ORDレコード
ord-2da47c2e998b46a59f24f792341344cc
出典データセット
uspto-grants-1996_09
特許番号
US05557002

反応ノート

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