4-Benzyloxy [4-(4-pyridyl)piperazin-2-one-1-yl]benzene → 4-[4-(4-Pyridyl)piperazin-2-one-1-yl]phenol

HRID 743852

反応式

HRID 743852 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)[CH2:17][C:16]2=[O:27])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>CO.O1CCCC1.[Pd]>[N:24]1[CH:25]=[CH:26][C:21]([N:18]2[CH2:19][CH2:20][N:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[C:16](=[O:27])[CH2:17]2)=[CH:22][CH:23]=1

参加物

6

反応物 2

HCID 542272954-Benzyloxy [4-(4-pyridyl)piperazin-2-one-1-yl]benzeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 189184154-[4-(4-Pyridyl)piperazin-2-one-1-yl]phenol

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the product of step (i) (1.1 g) in a mixture of methanol (500 ml) and tetrahydrofuran (100 ml) was added 30% palladium-on-charcoal catalyst (300 mg) and the mixture stirred in an atmosphere of hydrogen at ambient temperature and pressure until all the starting material had been consumed. After removal of the catalyst by filtration, the solvent was evaporated in vacuo to give 4-[4-(4-pyridyl)piperazin-2-one-1-yl]phenol as a colourless solid, essentially one spot by tlc, which was used without further purification or characterisation.

後処理

  1. custompressure until all the starting material had been consumed
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-1e2ddc42f7424b8fbe1cba4ab884d3a6
出典データセット
uspto-grants-1996_09
特許番号
US05556977

関連ノート

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